Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.44 |
| ▸ | PTPRF | P10586 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 2/20 | 0.37 |
| ▸ | CES1 | P23141 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | CA6 | P23280 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1298701 | 0.81 | MEN1 (0.54) | MEN1KMT2ATDP1PTPN2PTPN1 | |
| SCHEMBL4652941 | 0.80 | ALDH1A1 (0.56) | ALDH1A1ALOX15TSHRCES2CES1 | |
| SCHEMBL12648858 | 0.79 | MEN1 (0.52) | MEN1KMT2ATDP1PTPN2PTPN1 | |
| SCHEMBL40612 | 0.79 | ALDH1A1 (0.65) | MEN1KMT2ATDP1PTPN2PTPN1 | |
| SCHEMBL30516691 | 0.79 | ALDH1A1 (0.65) | MEN1KMT2ATDP1PTPN2PTPN1 | |
| SCHEMBL3839465 | 0.79 | KMT2A (0.52) | MEN1KMT2ATDP1PTPN2PTPN1 | |
| SCHEMBL967996 | 0.77 | ALDH1A1 (0.56) | MEN1KMT2ATDP1PTPN2PTPN1 | |
| SCHEMBL8813905 | 0.77 | ALDH1A1 (0.56) | MEN1KMT2ATDP1PTPN2PTPN1 | |
| SCHEMBL11101821 | 0.77 | MEN1 (0.50) | MEN1KMT2ATDP1PTPN2PTPN1 | |
| SCHEMBL14439684 | 0.77 | MEN1 (0.50) | MEN1KMT2ATDP1PTPN2PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110184173-A1 | Pyripyropene Derivatives Having An ACAT2-Inhibiting Activity | THE KITASATO INSTITUTE (JP) | 2011-07-28 | — | — | US | claimed |
| EP-2228376-A1 | PYRIPYROPENE DERIVATIVE HAVING ACAT2-INHIBITING ACTIVITY | The Kitasato Institute (JP) | 2010-09-15 | — | — | EP | claimed |
| EP-2228376-B1 | PYRIPYROPENE DERIVATIVE HAVING ACAT2-INHIBITING ACTIVITY | KITASATO INST (JP) | 2015-06-03 | — | — | EP | disclosed |
| US-8519128-B2 | Pyripyropene derivatives having an ACAT2-inhibiting activity | THE KITASATO INSTITUTE (JP) | 2013-08-27 | — | — | US | disclosed |
| US-20110184173-A1 | Pyripyropene Derivatives Having An ACAT2-Inhibiting Activity | THE KITASATO INSTITUTE (JP) | 2011-07-28 | — | — | US | disclosed |
| EP-2228376-A1 | PYRIPYROPENE DERIVATIVE HAVING ACAT2-INHIBITING ACTIVITY | The Kitasato Institute (JP) | 2010-09-15 | — | — | EP | disclosed |
| US-5985869-A | USEFUL AS VASODILATORS, HYPOTENSIVE AGENTS, WATER DIURETICS, PLATELET AGGLUTINATION INHIBITORS | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1999-11-16 | — | — | US | disclosed |
| US-5753677-A | Benzoheterocyclic compounds | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1998-05-19 | — | — | US | disclosed |
| US-5559230-A | VASOPRESSIN ANTAGONISTS, QUINOLINES, BENZAZEPINES, VASODILATION, HYPOTENSIVE AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-09-24 | — | — | US | disclosed |
| EP-0450097-B1 | BENZOHETEROCYCLIC COMPOUNDS | OTSUKA PHARMA CO LTD (JP) | 1996-04-24 | — | — | EP | disclosed |
| EP-0602209-A1 | OXYTOCIN ANTAGONIST | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-06-22 | — | — | EP | disclosed |
| WO-1994001113-A1 | OXYTOCIN ANTAGONIST | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1994-01-20 | — | — | WO | disclosed |
| EP-0450097-A1 | BENZOHETEROCYCLIC COMPOUNDS. | OTSUKA PHARMA CO LTD (JP) | 1991-10-09 | — | — | EP | disclosed |
| WO-1991005549-A1 | BENZOHETEROCYCLIC COMPOUNDS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-05-02 | — | — | WO | disclosed |
| US-3936462-A | CNS DEPRESSANT, ANALGESIC | STERLING DRUG INC. (US) | 1976-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110184173-A1 | Pyripyropene Derivatives Having An ACAT2-Inhibiting Activity | ACAT2, ACAT1, AGPAT2 | MEN1 3873/4885KMT2A 935/4885TDP1 1436/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.