Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.35 |
| ▸ | ABL1 | P00519 | 3/20 | 0.35 |
| ▸ | BCR | P11274 | 3/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.35 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 4/20 | 0.34 |
| ▸ | BRAF | P15056 | 4/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21633859 | 0.90 | LRRK2 (0.38) | LRRK2FSCN1PTPN11KCNQ3KCNQ2 | |
| SCHEMBL21653242 | 0.88 | LRRK2 (0.40) | LRRK2ABL1FSCN1PTPN11KCNQ3 | |
| SCHEMBL21653261 | 0.87 | LRRK2 (0.39) | LRRK2PDE10ARAF1BRAFSMN1; SMN2 | |
| SCHEMBL21653152 | 0.85 | BACE1 (0.42) | PDE10AABL1BCRHDAC1HDAC3 | |
| SCHEMBL21653151 | 0.80 | PDE10A (0.35) | PDE10ASMN1; SMN2NPC1POLBRAB9A | |
| SCHEMBL21653089 | 0.80 | PDE10A (0.35) | PDE10AFSCN1KCNQ3KCNQ2AR | |
| SCHEMBL21653254 | 0.78 | LRRK2 (0.37) | LRRK2SMN1; SMN2AR | |
| SCHEMBL21652879 | 0.77 | LRRK2 (0.40) | LRRK2ABL1FSCN1 | |
| SCHEMBL21653156 | 0.76 | PDE10A (0.38) | PDE10ASMN1; SMN2NPC1POLBRAB9A | |
| SCHEMBL21653081 | 0.73 | SMN1; SMN2 (0.38) | PDE10ARAF1BRAFSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020023657-A1 | PYRIDIN-2-ONE COMPOUNDS USEFUL AS SMARCA2 ANTAGONISTS | Epizyme, Inc. (US) | 2020-01-30 | — | — | WO | disclosed |