Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.42 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 4/20 | 0.37 |
| ▸ | BRAF | P15056 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 2/20 | 0.35 |
| ▸ | BCR | P11274 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21653259 | 0.89 | BACE1 (0.39) | BACE1BACE2RAF1BRAFKMT2A | |
| SCHEMBL21653081 | 0.89 | SMN1; SMN2 (0.38) | BACE1BACE2RAF1BRAFKMT2A | |
| SCHEMBL21653244 | 0.88 | BACE1 (0.39) | BACE1BACE2KMT2AABL1MAPT | |
| SCHEMBL21652875 | 0.85 | LRRK2 (0.39) | BACE1RAF1BRAFKCNH2PDE10A | |
| SCHEMBL21653156 | 0.82 | PDE10A (0.38) | BACE1KMT2AKCNH2PDE10ASMN1; SMN2 | |
| SCHEMBL21653229 | 0.81 | RAB9A (0.42) | BACE1BACE2KMT2ASMN1; SMN2MAPK14 | |
| SCHEMBL21653075 | 0.79 | KMT2A (0.36) | BACE1BACE2KMT2AABL1MAPT | |
| SCHEMBL21653151 | 0.78 | PDE10A (0.35) | KMT2APDE10ASMN1; SMN2MAPTNPC1 | |
| SCHEMBL21653089 | 0.78 | PDE10A (0.35) | PDE10AMAPTTP53MAPK1 | |
| SCHEMBL21653261 | 0.76 | LRRK2 (0.39) | RAF1BRAFKMT2APDE10ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020023657-A1 | PYRIDIN-2-ONE COMPOUNDS USEFUL AS SMARCA2 ANTAGONISTS | Epizyme, Inc. (US) | 2020-01-30 | — | — | WO | disclosed |