Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 6/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.32 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.32 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21653232 | 0.90 | MAPT (0.34) | MAPTMAPK1KMT2AARENPP2 | |
| SCHEMBL21653146 | 0.89 | MET (0.33) | MAPTMAPK1TP53SMN1; SMN2KMT2A | |
| SCHEMBL21653256 | 0.89 | MAPT (0.34) | MAPTMAPK1TP53NPC1RAB9A | |
| SCHEMBL21653156 | 0.86 | PDE10A (0.38) | PDE10AMAPTMAPK1TP53NPC1 | |
| SCHEMBL21653089 | 0.85 | PDE10A (0.35) | PDE10AMAPTMAPK1TP53AR | |
| SCHEMBL21653122 | 0.83 | ALDH1A1 (0.40) | MAPTTP53NPC1RAB9ALMNA | |
| SCHEMBL21653160 | 0.81 | MEN1 (0.35) | MAPTMAPK1TP53NPC1RAB9A | |
| SCHEMBL21653276 | 0.81 | L3MBTL1 (0.36) | PDE10AMAPTTP53SMN1; SMN2TAS1R3 | |
| SCHEMBL21633869 | 0.80 | TP53 (0.35) | MAPTMAPK1TP53NPC1RAB9A | |
| SCHEMBL21652875 | 0.80 | LRRK2 (0.39) | PDE10ANPC1RAB9ASMN1; SMN2AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020023657-A1 | PYRIDIN-2-ONE COMPOUNDS USEFUL AS SMARCA2 ANTAGONISTS | Epizyme, Inc. (US) | 2020-01-30 | — | — | WO | disclosed |