Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | FSCN1 | Q16658 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.32 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.32 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.32 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.32 |
| ▸ | XDH | P47989 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.31 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21652879 | 0.89 | LRRK2 (0.40) | LRRK2FSCN1TP53XDHABL1 | |
| SCHEMBL21652875 | 0.88 | LRRK2 (0.39) | LRRK2FSCN1KCNQ3KCNQ2PTPN11 | |
| SCHEMBL21633859 | 0.87 | LRRK2 (0.38) | LRRK2FSCN1KCNQ3KCNQ2PTPN11 | |
| SCHEMBL21653244 | 0.85 | BACE1 (0.39) | FSCN1KCNQ3KCNQ2PTPN11PIM1 | |
| SCHEMBL21653260 | 0.83 | PTPN11 (0.32) | FSCN1TP53PTPN11PIM1PIM3 | |
| SCHEMBL21653256 | 0.80 | MAPT (0.34) | FSCN1TP53ARMAPT | |
| SCHEMBL21652914 | 0.77 | MAPT (0.31) | PIM1PIM3PIM2MAPT | |
| SCHEMBL21653164 | 0.76 | MAPT (0.37) | FSCN1MAPT | |
| SCHEMBL21653261 | 0.76 | LRRK2 (0.39) | LRRK2TP53MAPT | |
| SCHEMBL21652862 | 0.75 | MAPT (0.32) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020023657-A1 | PYRIDIN-2-ONE COMPOUNDS USEFUL AS SMARCA2 ANTAGONISTS | Epizyme, Inc. (US) | 2020-01-30 | — | — | WO | disclosed |