Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 8/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 4/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.31 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21653248 | 0.89 | MET (0.34) | METAXLMAPTMAPK1KMT2A | |
| SCHEMBL21653156 | 0.87 | PDE10A (0.38) | GSK3BDAOMAPTMAPK1KMT2A | |
| SCHEMBL21633837 | 0.87 | MAPT (0.39) | METAXLMAPTMAPK1KMT2A | |
| SCHEMBL21653164 | 0.86 | MAPT (0.37) | GSK3BDAOMAPTMAPK1KMT2A | |
| SCHEMBL21653057 | 0.86 | MAPT (0.37) | METAXLMAPTMAPK1KMT2A | |
| SCHEMBL21653062 | 0.86 | MAPT (0.32) | METAXLMAPTMAPK1KMT2A | |
| SCHEMBL21653146 | 0.86 | MET (0.33) | METAXLMAPTMAPK1KMT2A | |
| SCHEMBL21653264 | 0.85 | MAPT (0.36) | GSK3BDAOMAPTMAPK1KMT2A | |
| SCHEMBL21653010 | 0.85 | MEN1 (0.32) | METAXLMAPTMAPK1KMT2A | |
| SCHEMBL21653113 | 0.84 | ALDH1A1 (0.38) | GSK3BDAOMAPTMAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020023657-A1 | PYRIDIN-2-ONE COMPOUNDS USEFUL AS SMARCA2 ANTAGONISTS | Epizyme, Inc. (US) | 2020-01-30 | — | — | WO | disclosed |