Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.35 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.33 |
| ▸ | MEN1 | O00255 | 5/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21653074 | 0.91 | GSK3B (0.38) | MAPTMAPK1GSK3BDAOKMT2A | |
| SCHEMBL21653130 | 0.88 | MAPT (0.35) | MAPTMAPK1FSCN1KMT2AMEN1 | |
| SCHEMBL21653156 | 0.87 | PDE10A (0.38) | MAPTMAPK1GSK3BDAOKMT2A | |
| SCHEMBL21652918 | 0.86 | GSK3B (0.36) | MAPTMAPK1GSK3BDAOKMT2A | |
| SCHEMBL21653256 | 0.86 | MAPT (0.34) | MAPTMAPK1FSCN1KMT2AMEN1 | |
| SCHEMBL21653264 | 0.85 | MAPT (0.36) | MAPTMAPK1GSK3BDAOKMT2A | |
| SCHEMBL21653148 | 0.85 | MAPT (0.36) | MAPTMAPK1FSCN1KMT2AMEN1 | |
| SCHEMBL21653131 | 0.84 | MAPT (0.35) | MAPTMAPK1FSCN1KMT2AMEN1 | |
| SCHEMBL21653141 | 0.84 | MAPT (0.36) | MAPTMAPK1FSCN1KMT2AMEN1 | |
| SCHEMBL21653244 | 0.82 | BACE1 (0.39) | MAPTMAPK1FSCN1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020023657-A1 | PYRIDIN-2-ONE COMPOUNDS USEFUL AS SMARCA2 ANTAGONISTS | Epizyme, Inc. (US) | 2020-01-30 | — | — | WO | disclosed |