Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 11/20 | 0.64 |
| ▸ | NPC1 | O15118 | 10/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.64 |
| ▸ | MAPT | P10636 | 5/20 | 0.64 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.64 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.64 |
| ▸ | RELA | Q04206 | 2/20 | 0.64 |
| ▸ | PKM | P14618 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CASP3 | P42574 | 4/20 | 0.59 |
| ▸ | SENP7 | Q9BQF6 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | NR0B1 | P51843 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21653176 | 0.79 | MEN1 (0.58) | RAB9ANPC1SMN1; SMN2MAPTPKM | |
| SCHEMBL108116 | 0.79 | NPC1 (1.00) | RAB9ANPC1SMN1; SMN2MAPTNFKB1 | |
| SCHEMBL21652915 | 0.77 | CREBBP (0.55) | RAB9ANPC1MAPTALDH1A1KMT2A | |
| SCHEMBL21653182 | 0.77 | KMT2A (0.52) | RAB9ANPC1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL6848423 | 0.77 | RAB9A (0.84) | RAB9ANPC1SMN1; SMN2MAPTNFKB1 | |
| SCHEMBL21652920 | 0.77 | MAPT (0.42) | RAB9ANPC1MAPTKMT2ACYP1A2 | |
| SCHEMBL8768779 | 0.76 | RAB9A (0.82) | RAB9ANPC1SMN1; SMN2MAPTNFKB1 | |
| SCHEMBL21653184 | 0.76 | KCNQ3 (0.53) | RAB9ANPC1SMN1; SMN2MAPTPKM | |
| SCHEMBL21653193 | 0.76 | KCNQ3 (0.53) | RAB9ANPC1MAPTPKMKMT2A | |
| SCHEMBL21653177 | 0.76 | MAPT (0.46) | RAB9ANPC1SMN1; SMN2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020023657-A1 | PYRIDIN-2-ONE COMPOUNDS USEFUL AS SMARCA2 ANTAGONISTS | Epizyme, Inc. (US) | 2020-01-30 | — | — | WO | disclosed |