Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 7/20 | 0.46 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | BRD4 | O60885 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | BRD2 | P25440 | 1/20 | 0.40 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.40 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21653246 | 0.84 | MAPT (0.43) | CREBBPMAPTTP53RAB9ANPC1 | |
| SCHEMBL21653182 | 0.83 | KMT2A (0.52) | MAPTTP53RAB9ANPC1POLB | |
| SCHEMBL21652920 | 0.83 | MAPT (0.42) | CREBBPMAPTRPS6KA2TP53RAB9A | |
| SCHEMBL21653176 | 0.80 | MEN1 (0.58) | MAPTRAB9ANPC1POLBLMNA | |
| SCHEMBL21653116 | 0.80 | LMNA (0.54) | MAPTRPS6KA2RAB9ANPC1LMNA | |
| SCHEMBL21653177 | 0.80 | MAPT (0.46) | MAPTRAB9ANPC1POLBALDH1A1 | |
| SCHEMBL21653096 | 0.78 | GRM1 (0.46) | MAPTRAB9ANPC1POLBALDH1A1 | |
| SCHEMBL21653108 | 0.77 | CA9 (0.43) | MAPTTP53RAB9ANPC1LMNA | |
| SCHEMBL21653203 | 0.77 | SMN1; SMN2 (0.46) | MAPTTP53RAB9APOLBBRD4 | |
| SCHEMBL21653193 | 0.77 | KCNQ3 (0.53) | MAPTTP53RAB9ANPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020023657-A1 | PYRIDIN-2-ONE COMPOUNDS USEFUL AS SMARCA2 ANTAGONISTS | Epizyme, Inc. (US) | 2020-01-30 | — | — | WO | disclosed |