Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.58 |
| ▸ | NPC1 | O15118 | 4/20 | 0.58 |
| ▸ | RAB9A | P51151 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 6/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.50 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.50 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.50 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 3/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21653184 | 0.89 | KCNQ3 (0.53) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL21653193 | 0.89 | KCNQ3 (0.53) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL21653182 | 0.85 | KMT2A (0.52) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL21653177 | 0.84 | MAPT (0.46) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL21653190 | 0.84 | ALDH1A1 (0.54) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL21653246 | 0.81 | MAPT (0.43) | NPC1RAB9AKDM4EMAPTMAOB | |
| SCHEMBL21652915 | 0.80 | CREBBP (0.55) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL21652920 | 0.80 | MAPT (0.42) | MEN1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL21652987 | 0.79 | RAB9A (0.64) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL21653265 | 0.78 | MEN1 (0.44) | MEN1KMT2ANPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020023657-A1 | PYRIDIN-2-ONE COMPOUNDS USEFUL AS SMARCA2 ANTAGONISTS | Epizyme, Inc. (US) | 2020-01-30 | — | — | WO | disclosed |