Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 known ✓ | Q9Y5N1 | 2/20 | 0.81 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.81 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.81 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.81 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.81 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.81 |
| ▸ | HRH4 | Q9H3N8 | 10/20 | 0.81 |
| ▸ | HTR1D | P28221 | 1/20 | 0.81 |
| ▸ | HTR7 | P34969 | 1/20 | 0.81 |
| ▸ | HTR3A | P46098 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL2165298 | 1.00 | HRH4 (0.81) | HRH4HRH3HTR1AADRA2AADRA2C | |
| SCHEMBL2166660 | 0.90 | HRH4 (1.00) | HRH4HRH3HTR1AADRA2AADRA2C | |
| SCHEMBL604430 | 0.78 | HRH4 (0.76) | HRH4HRH3HTR1AADRA2AADRA2C | |
| SCHEMBL2166460 | 0.77 | HRH4 (1.00) | HRH4HRH3HTR1AADRA2AADRA2C | |
| SCHEMBL2166566 | 0.77 | HRH4 (0.94) | HRH4HRH3HTR1AADRA2AADRA2C | |
| SCHEMBL2167865 | 0.77 | HRH4 (1.00) | HRH4HRH3HTR1AADRA2AADRA2C | |
| SCHEMBL2808801 | 0.76 | HRH4 (0.72) | HRH4HRH3HTR1AADRA2AADRA2C | |
| SCHEMBL2805813 | 0.76 | HRH4 (0.61) | HRH4HRH3HTR1AADRA2AADRA2C | |
| SCHEMBL2166683 | 0.76 | HRH4 (0.72) | HRH4HRH3HTR1AADRA2AADRA2C | |
| SCHEMBL2165529 | 0.76 | HRH4 (0.72) | HRH4HRH3HTR1AADRA2AADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7985745-B2 | Including inflammatory pain, post surgical pain, and neuropathic pain; administering a histamine H4 receptor ligand alone or in combination with a histamine H1, H2, or H3 receptor antagonist or an enzyme inhibitor | ABBOTT LABORATORIES (US) | 2011-07-26 | — | — | US | disclosed |
| US-20080194538-A1 | Method for Pain Treatment | ABBVIE INC. | 2008-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194538-A1 | Method for Pain Treatment | HRH4, HRH3, HRH2 | HRH3 2/4885HTR1A 90/4885ADRA2A 159/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.