Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | FSCN1 | Q16658 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 2/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21653152 | 0.88 | BACE1 (0.42) | BACE1BACE2KMT2AMAPTMAPK1 | |
| SCHEMBL21653259 | 0.86 | BACE1 (0.39) | BACE1BACE2KMT2AMAPTMAPK1 | |
| SCHEMBL21653260 | 0.85 | PTPN11 (0.32) | FSCN1MAPTPTPN11PIM1PIM3 | |
| SCHEMBL21653242 | 0.85 | LRRK2 (0.40) | BACE1FSCN1MAPTPTPN11ABL1 | |
| SCHEMBL21653164 | 0.82 | MAPT (0.37) | KMT2AFSCN1MAPTMAPK1ALDH1A1 | |
| SCHEMBL21653130 | 0.80 | MAPT (0.35) | KMT2AFSCN1MAPTMAPK1ALDH1A1 | |
| SCHEMBL21652914 | 0.79 | MAPT (0.31) | KMT2AMAPTPIM1PIM3PIM2 | |
| SCHEMBL21653256 | 0.78 | MAPT (0.34) | KMT2AFSCN1MAPTMAPK1ALDH1A1 | |
| SCHEMBL21652862 | 0.77 | MAPT (0.32) | KMT2AMAPTMAPK1TDP1KDM4E | |
| SCHEMBL21653081 | 0.76 | SMN1; SMN2 (0.38) | BACE1BACE2KMT2AMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020023657-A1 | PYRIDIN-2-ONE COMPOUNDS USEFUL AS SMARCA2 ANTAGONISTS | Epizyme, Inc. (US) | 2020-01-30 | — | — | WO | disclosed |