Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | NPC1 | O15118 | 5/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | HPGD | P15428 | 5/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.49 |
| ▸ | RELA | Q04206 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 4/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21653034 | 0.88 | ALDH1A1 (0.41) | ALDH1A1KDM4EMEN1KMT2ANPC1 | |
| SCHEMBL21653071 | 0.85 | KMT2A (0.49) | ALDH1A1KDM4EMEN1KMT2ANPC1 | |
| SCHEMBL21653238 | 0.85 | SMN1; SMN2 (0.38) | ALDH1A1KDM4EMEN1KMT2ANPC1 | |
| SCHEMBL21652970 | 0.85 | NPC1 (0.41) | ALDH1A1KDM4EMEN1KMT2ANPC1 | |
| SCHEMBL21653229 | 0.82 | RAB9A (0.42) | ALDH1A1KDM4EMEN1KMT2ANPC1 | |
| SCHEMBL21653250 | 0.82 | ALDH1A1 (0.43) | ALDH1A1KDM4EMEN1KMT2ANPC1 | |
| SCHEMBL21653240 | 0.81 | ALDH1A1 (0.45) | ALDH1A1KDM4EMEN1KMT2ANPC1 | |
| SCHEMBL21652912 | 0.81 | KDM4E (0.45) | ALDH1A1KDM4EMEN1KMT2ANPC1 | |
| SCHEMBL21653124 | 0.81 | PPARG (0.40) | ALDH1A1KDM4EMEN1KMT2ANPC1 | |
| SCHEMBL21653123 | 0.81 | HIF1A (0.41) | ALDH1A1KDM4EMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020023657-A1 | PYRIDIN-2-ONE COMPOUNDS USEFUL AS SMARCA2 ANTAGONISTS | Epizyme, Inc. (US) | 2020-01-30 | — | — | WO | disclosed |