Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | ESRRG | P62508 | 2/20 | 0.37 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21653230 | 0.85 | ALDH1A1 (0.49) | NPC1RAB9ARXFP1KMT2AMEN1 | |
| SCHEMBL21653238 | 0.85 | SMN1; SMN2 (0.38) | NPC1RAB9ARXFP1HIF1AEPAS1 | |
| SCHEMBL21653071 | 0.85 | KMT2A (0.49) | NPC1RAB9ARXFP1KMT2APOLB | |
| SCHEMBL21653123 | 0.81 | HIF1A (0.41) | NPC1RAB9AHIF1AEPAS1KMT2A | |
| SCHEMBL21653240 | 0.79 | ALDH1A1 (0.45) | NPC1RAB9ARXFP1KMT2APOLB | |
| SCHEMBL21653250 | 0.78 | ALDH1A1 (0.43) | NPC1RAB9ARXFP1KMT2APOLB | |
| SCHEMBL21653229 | 0.78 | RAB9A (0.42) | NPC1RAB9AKMT2APOLBMEN1 | |
| SCHEMBL21653124 | 0.77 | PPARG (0.40) | NPC1RAB9ARXFP1KMT2APOLB | |
| SCHEMBL21653273 | 0.76 | ALDH1A1 (0.46) | NPC1RAB9AKMT2APOLBMEN1 | |
| SCHEMBL21653203 | 0.74 | SMN1; SMN2 (0.46) | RAB9AKMT2APOLBMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020023657-A1 | PYRIDIN-2-ONE COMPOUNDS USEFUL AS SMARCA2 ANTAGONISTS | Epizyme, Inc. (US) | 2020-01-30 | — | — | WO | disclosed |