Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | CA9 | Q16790 | 3/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21653119 | 0.88 | ALDH1A1 (0.43) | MEN1KMT2ANPC1RAB9ACA9 | |
| SCHEMBL21653073 | 0.77 | RAB9A (0.41) | MEN1KMT2ANPC1RAB9ACA9 | |
| SCHEMBL21653053 | 0.76 | DAO (0.45) | MEN1KMT2ARAB9APOLBKDM4E | |
| SCHEMBL21653068 | 0.76 | TAS2R8 (0.47) | MEN1KMT2ANPC1RAB9APOLB | |
| SCHEMBL21653268 | 0.75 | MAPT (0.41) | MEN1KMT2ANPC1RAB9APOLB | |
| SCHEMBL21653108 | 0.75 | CA9 (0.43) | NPC1RAB9ACA9CA12KDM4E | |
| SCHEMBL4428829 | 0.74 | MEN1 (0.45) | MEN1KMT2ANPC1RAB9APOLB | |
| SCHEMBL4355046 | 0.73 | NPC1 (0.55) | MEN1KMT2ANPC1RAB9APOLB | |
| SCHEMBL21653182 | 0.73 | KMT2A (0.52) | MEN1KMT2ANPC1RAB9ACA9 | |
| SCHEMBL21652915 | 0.73 | CREBBP (0.55) | MEN1KMT2ANPC1RAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020023657-A1 | PYRIDIN-2-ONE COMPOUNDS USEFUL AS SMARCA2 ANTAGONISTS | Epizyme, Inc. (US) | 2020-01-30 | — | — | WO | disclosed |