Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 1/20 | 0.35 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.35 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.35 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16860600 | 0.73 | MEN1 (0.37) | GRIA1GRIA2GRIA3GRIA4LMNA | |
| SCHEMBL21653342 | 0.71 | LMNA (0.38) | LMNA | |
| SCHEMBL18595554 | 0.67 | ALDH1A1 (0.32) | TSHR | |
| SCHEMBL21907095 | 0.67 | ACSS2 (0.41) | CYP1A2CYP3A4PTGER4 | |
| SCHEMBL25861375 | 0.61 | ALDH1A1 (0.33) | MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL22648854 | 0.61 | KDM1A (0.51) | LMNAMEN1TSHRKMT2ASMN1; SMN2 | |
| SCHEMBL22479058 | 0.61 | GRIK1 (0.37) | LMNATSHR | |
| SCHEMBL27300532 | 0.58 | — | — | |
| SCHEMBL16860573 | 0.58 | KAT2B (0.32) | LMNAMEN1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL20149586 | 0.57 | ALDH1A1 (0.37) | LMNAMEN1CYP1A2CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020023657-A1 | PYRIDIN-2-ONE COMPOUNDS USEFUL AS SMARCA2 ANTAGONISTS | Epizyme, Inc. (US) | 2020-01-30 | — | — | WO | disclosed |