Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | TNFRSF1A | P19438 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21654139 | 0.85 | KCNH2 (0.41) | PRMT6KCNH2CA12CA9ERN1 | |
| SCHEMBL12187101 | 0.81 | HDAC6 (0.36) | KMT2A | |
| SCHEMBL21654295 | 0.73 | POLB (0.31) | — | |
| SCHEMBL21654340 | 0.73 | KCNH2 (0.38) | PRMT6KCNH2ERN1HDAC2LTA4H | |
| SCHEMBL6193544 | 0.70 | DPP4 (0.53) | PRMT6KCNH2ERN1HDAC2LTA4H | |
| SCHEMBL21654153 | 0.66 | KMT2A (0.46) | KMT2AALOX5PTGS1PTGS2 | |
| SCHEMBL7396854 | 0.66 | KCNH2 (0.46) | PRMT6KCNH2ERN1HDAC2LTA4H | |
| SCHEMBL22733865 | 0.65 | KCNH2 (0.48) | PRMT6KCNH2ERN1LTA4HKMT2A | |
| SCHEMBL2600074 | 0.64 | HDAC6 (0.39) | KMT2A | |
| SCHEMBL18876355 | 0.63 | ALDH1A1 (0.39) | PRMT6KCNH2LTA4HKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10993938-B2 | Lactam compound, preparation method and use thereof | OCEAN UNIVERSITY OF CHINA (CN) | 2021-05-04 | — | — | US | disclosed |
| US-20200030312-A1 | Lactam Compound, Preparation Method and Use thereof | OCEAN UNIVERSITY OF CHINA (CN) | 2020-01-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200030312-A1 | Lactam Compound, Preparation Method and Use thereof | FURIN, PEPD, PIN1 | PRMT6 1762/4885KCNH2 4596/4885CA12 2391/4885 |
| US-10993938-B2 | Lactam compound, preparation method and use thereof | FURIN, PEPD, PIN1 | PRMT6 1762/4885KCNH2 4596/4885CA12 2391/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.