Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 10/20 | 0.58 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.56 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2165836 | 1.00 | SIGMAR1 (0.58) | SIGMAR1GRIN2BGRIN1 | |
| SCHEMBL2166535 | 1.00 | SIGMAR1 (0.58) | SIGMAR1GRIN2BGRIN1 | |
| Hydrochloric Acid SCHEMBL1299380 | 0.99 | SIGMAR1 (0.60) | SIGMAR1GRIN2BGRIN1 | |
| Hydrochloric Acid SCHEMBL1299141 | 0.99 | SIGMAR1 (0.60) | SIGMAR1GRIN2BGRIN1 | |
| Hydrochloric Acid SCHEMBL1299139 | 0.99 | SIGMAR1 (0.60) | SIGMAR1GRIN2BGRIN1 | |
| SCHEMBL1299103 | 0.92 | HTR2C (0.59) | SIGMAR1GRIN2BGRIN1 | |
| SCHEMBL1299524 | 0.92 | HTR2C (0.59) | SIGMAR1GRIN2BGRIN1 | |
| SCHEMBL1299100 | 0.92 | HTR2C (0.59) | SIGMAR1GRIN2BGRIN1 | |
| Hydrochloric Acid SCHEMBL1298852 | 0.91 | HTR2C (0.58) | SIGMAR1GRIN2BGRIN1 | |
| Hydrochloric Acid SCHEMBL1298856 | 0.91 | HTR2C (0.58) | SIGMAR1GRIN2BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7985751-B2 | Piperazine derivatives | M'S SCIENCE CORPORATION (JP) | 2011-07-26 | — | — | US | claimed |
| US-20110218205-A1 | Piperazine derivatives | M'S SCIENCE CORP. | 2011-09-08 | — | — | US | disclosed |
| US-20110218205-A1 | Piperazine derivatives | M'S SCIENCE CORP. | 2011-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110218205-A1 | Piperazine derivatives | SIGMAR1, OPRK1, OPRM1 | SIGMAR1 1/4885GRIN2B 39/4885GRIN1 43/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.