SCHEMBL21661360

SCHEMBL21661360

CCCNC(=O)[C@@H]1CCNC1

nearest known ligand 0.60

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 1/20 0.60
CHRNB4 P30926 1/20 0.60
CHRNA3 P32297 1/20 0.60
CHRNA7 P36544 1/20 0.60
CHRNA4 P43681 1/20 0.60
GNAI3 P08754 1/20 0.59
GNAO1 P09471 1/20 0.59
GNAI1 P63096 1/20 0.59
HTR2C P28335 1/20 0.44
NAAA Q02083 1/20 0.44
KDM4E B2RXH2 2/20 0.43
HPGD P15428 1/20 0.43
HSD17B10 Q99714 1/20 0.43
PRCP P42785 2/20 0.42
DPP4 P27487 1/20 0.40
EPHX1 P07099 2/20 0.40
ALDH1A1 P00352 2/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
GRM4 Q14833 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2149339 1.00 CHRNB2 (0.60) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL30914545 0.91 GNAI3 (0.51) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL4635163 0.90 GNAI3 (0.69) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL13285080 0.90 CHRNB2 (0.57) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL1438745 0.89 GNAI3 (0.73) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL12574191 0.87 GNAI3 (0.51) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL3935665 0.87 GNAI3 (0.51) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL22179378 0.87 GNAI3 (0.80) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL22178856 0.87 GNAI3 (0.80) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL22179122 0.87 GNAI3 (0.80) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024100139-A1 USE OF IFN-I ACTIVITY AS A BIOMARKER FOR TLR INHIBITOR TREATMENT MERCK PATENT GMBH (DE) 2024-05-16 WO disclosed
WO-2020025517-A1 TLR7/8 ANTAGONISTS AND USES THEREOF MERCK PATENT GMBH (DE) 2020-02-06 WO disclosed