Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.44 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | AKT2 | P31751 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.43 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.43 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21667344 | 0.91 | EGFR (0.54) | EGFRADORA2BKCNN3P2RX7CHEK1 | |
| SCHEMBL21667342 | 0.84 | GRIN1 (0.52) | EGFRADORA2BP2RX7CHEK1DAPK3 | |
| SCHEMBL21667387 | 0.83 | PGR (0.47) | P2RX7MEN1KMT2A | |
| SCHEMBL21667215 | 0.82 | SMN1; SMN2 (0.53) | KDM4ENPSR1MEN1CYP1A2GAA | |
| SCHEMBL21667218 | 0.79 | KMT2A (0.42) | DAOMEN1GAAKMT2AMAPT | |
| SCHEMBL16321171 | 0.78 | HTT (0.49) | DAOCNR1CYP3A4 | |
| SCHEMBL16321172 | 0.78 | HTT (0.49) | DAOCNR1CYP3A4 | |
| SCHEMBL21667384 | 0.75 | GPR84 (0.45) | ADORA2BDAOKDM4EMEN1CYP1A2 | |
| SCHEMBL21667214 | 0.74 | SMN1; SMN2 (0.47) | KDM4ENPSR1MEN1KMT2AMAPT | |
| SCHEMBL21667382 | 0.73 | ADORA1 (0.49) | DAOMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3702352-A1 | PYRIMIDINEDIONE COMPOUND AGAINST CARDIAC CONDITIONS | Myokardia, Inc. (US) | 2020-09-02 | — | — | EP | disclosed |
| EP-3010910-B1 | PYRIMIDINEDIONE COMPOUNDS AGAINST CARDIAC CONDITIONS | MYOKARDIA INC (US) | 2020-02-05 | — | — | EP | disclosed |