Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 7/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16784833 | 0.82 | HSD11B1 (0.46) | HSD11B1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL13015613 | 0.79 | PSEN1 (0.44) | HSD11B1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL13183529 | 0.79 | HSD11B1 (0.43) | HSD11B1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7866846 | 0.77 | HSD11B1 (0.44) | HSD11B1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL774178 | 0.75 | ACHE (0.52) | HSD11B1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL27326103 | 0.75 | ACHE (0.52) | HSD11B1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3015868 | 0.75 | PSEN1 (0.54) | HSD11B1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL27326106 | 0.75 | ACHE (0.52) | HSD11B1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3775543 | 0.75 | AKR1C3 (0.46) | HSD11B1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL31395296 | 0.74 | L3MBTL1 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020028482-A1 | SMALL MOLECULES THAT SENSITIZE HIV-1 INFECTED CELLS TO ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2020-02-06 | — | — | WO | disclosed |