Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9892806 | 0.82 | KDM4E (0.37) | THRBSMN1; SMN2 | |
| SCHEMBL8388696 | 0.80 | ALDH1A1 (0.40) | THRBSMN1; SMN2RETKDR | |
| SCHEMBL13262109 | 0.77 | THRB (0.35) | THRBSMN1; SMN2RET | |
| SCHEMBL13890431 | 0.77 | MAPK14 (0.37) | THRBSMN1; SMN2 | |
| SCHEMBL24033650 | 0.75 | — | — | |
| SCHEMBL18676475 | 0.75 | RET (0.31) | RETKDR | |
| SCHEMBL12650244 | 0.75 | TRPM8 (0.35) | SMN1; SMN2 | |
| SCHEMBL9892807 | 0.74 | CNR2 (0.37) | THRBSMN1; SMN2RET | |
| SCHEMBL1083433 | 0.73 | KDM4E (0.31) | — | |
| SCHEMBL23966692 | 0.73 | MEN1 (0.42) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210163464-A1 | PYRIDINE COMPOUND | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2021-06-03 | — | — | US | disclosed |
| US-10851092-B2 | Pyridine compound | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2020-12-01 | — | — | US | disclosed |
| US-20200039974-A1 | PYRIDINE COMPOUND | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2020-02-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200039974-A1 | PYRIDINE COMPOUND | RET, ROS1, ABL1 | THRB 1317/4885SMN1; SMN2 1797/4885RET 1/4885 |
| US-20210163464-A1 | PYRIDINE COMPOUND | RET, ABL1, ROS1 | THRB 1335/4885SMN1; SMN2 1897/4885RET 1/4885 |
| US-10851092-B2 | Pyridine compound | RET, ROS1, ABL1 | THRB 1317/4885SMN1; SMN2 1797/4885RET 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.