Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | SCN1A | P35498 | 2/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.37 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | SCN1B | Q07699 | 1/20 | 0.37 |
| ▸ | TNF | P01375 | 2/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | GPR6 | P46095 | 2/20 | 0.34 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | P4HB | P07237 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7216331 | 0.82 | GAA (0.41) | GAASMN1; SMN2SCN1ASCN5ASCN8A | |
| SCHEMBL2693324 | 0.78 | GAA (0.40) | GAASMN1; SMN2SCN1ASCN5ASCN8A | |
| SCHEMBL26946374 | 0.76 | SCN1A (0.44) | GAASMN1; SMN2SCN1ASCN5ASCN8A | |
| SCHEMBL30682614 | 0.75 | PDE2A (0.40) | GAASMN1; SMN2SCN1ASCN5ASCN8A | |
| SCHEMBL18450600 | 0.75 | PDE2A (0.40) | GAASMN1; SMN2SCN1ASCN5ASCN8A | |
| SCHEMBL29668996 | 0.75 | PDE2A (0.40) | GAASMN1; SMN2SCN1ASCN5ASCN8A | |
| SCHEMBL26352255 | 0.75 | GAA (0.38) | GAASMN1; SMN2SCN1ASCN5ASCN8A | |
| SCHEMBL22303850 | 0.75 | GAA (0.38) | GAASMN1; SMN2SCN1ASCN5ASCN8A | |
| SCHEMBL16952156 | 0.75 | GAA (0.38) | GAASMN1; SMN2SCN1ASCN5ASCN8A | |
| SCHEMBL27945350 | 0.75 | GAA (0.38) | GAASMN1; SMN2SCN1ASCN5ASCN8A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200039960-A1 | RORC2 INHIBITORS AND METHODS OF USE THEREOF | PFIZER INC. (US) | 2020-02-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200039960-A1 | RORC2 INHIBITORS AND METHODS OF USE THEREOF | RORC, RORB, RORA | GAA 924/4885SMN1; SMN2 3833/4885SCN1A 1944/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.