Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.40 |
| ▸ | BACE1 | P56817 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.38 |
| ▸ | KDM4A | O75164 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CASR | P41180 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2167223 | 0.86 | ADRB2 (0.43) | HTTL3MBTL1BACE1SMN1; SMN2 | |
| SCHEMBL15576272 | 0.80 | LMNA (0.47) | LMNAOPRM1OPRL1KMT2AL3MBTL1 | |
| SCHEMBL2778629 | 0.79 | LMNA (0.47) | LMNAOPRM1OPRL1KMT2AMEN1 | |
| SCHEMBL2151341 | 0.78 | LMNA (0.44) | LMNAKMT2AMEN1HTTL3MBTL1 | |
| SCHEMBL5069200 | 0.77 | RIPK1 (0.53) | LMNAKMT2AMEN1HTTL3MBTL1 | |
| SCHEMBL5065804 | 0.77 | RIPK1 (0.53) | LMNAKMT2AMEN1HTTL3MBTL1 | |
| SCHEMBL1529441 | 0.77 | RIPK1 (0.53) | LMNAKMT2AMEN1HTTL3MBTL1 | |
| SCHEMBL27821339 | 0.75 | LMNA (0.46) | LMNAKMT2AMEN1HTTL3MBTL1 | |
| SCHEMBL5069163 | 0.74 | ADRB3 (0.41) | KMT2AMEN1 | |
| SCHEMBL2151117 | 0.73 | LMNA (0.50) | LMNAOPRM1OPRL1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2340242-A2 | COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2011-07-06 | — | — | EP | disclosed |