Chlorpyrifos

Chlorpyrifos

SCHEMBL21680

CCOP(=S)(OCC)Oc1nc(Cl)c(Cl)cc1Cl

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 1.00
TDP1 Q9NUW8 5/20 1.00
MAPT P10636 4/20 1.00
TSHR P16473 4/20 1.00
CYP3A4 P08684 4/20 1.00
HSD17B10 Q99714 3/20 1.00
MAPK1 P28482 2/20 1.00
ALOX15 P16050 1/20 1.00
ALOX12 P18054 1/20 1.00
ATM Q13315 1/20 1.00
L3MBTL1 Q9Y468 1/20 1.00
MEN1 O00255 2/20 0.69
KMT2A Q03164 2/20 0.69
KDM4E B2RXH2 3/20 0.43
TP53 P04637 1/20 0.41
ACHE P22303 1/20 0.41
POLB P06746 1/20 0.37
CA12 O43570 1/20 0.35
CA1 P00915 1/20 0.35
CA3 P07451 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Chlorpyrifos SCHEMBL7908295 1.00 ALDH1A1 (1.00) ALDH1A1TDP1MAPTTSHRCYP3A4
Chlorpyrifos SCHEMBL14915191 0.98 ALDH1A1 (0.97) ALDH1A1TDP1MAPTTSHRCYP3A4
Chlorpyrifos SCHEMBL28566223 0.98 ALDH1A1 (0.97) ALDH1A1TDP1MAPTTSHRCYP3A4
Chlorpyrifos SCHEMBL18228939 0.98 ALDH1A1 (0.97) ALDH1A1TDP1MAPTTSHRCYP3A4
Chlorpyrifos SCHEMBL28343022 0.98 ALDH1A1 (0.97) ALDH1A1TDP1MAPTTSHRCYP3A4
Chlorpyrifos SCHEMBL28945660 0.98 ALDH1A1 (0.97) ALDH1A1TDP1MAPTTSHRCYP3A4
Chlorpyrifos SCHEMBL29011072 0.98 ALDH1A1 (0.97) ALDH1A1TDP1MAPTTSHRCYP3A4
Chlorpyrifos SCHEMBL29037286 0.97 ALDH1A1 (0.94) ALDH1A1TDP1MAPTTSHRCYP3A4
Chlorpyrifos SCHEMBL8502929 0.95 ALDH1A1 (0.91) ALDH1A1TDP1MAPTTSHRCYP3A4
Chlorpyrifos SCHEMBL1069405 0.94 ALDH1A1 (0.89) ALDH1A1TDP1MAPTTSHRCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 36326 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109476709-B Methods and compositions for conferring and/or enhancing herbicide tolerance using protoporphyrinogen oxidase or variants thereof FARMHANNONG Co.,Ltd. (KR) 2026-05-26 CN claimed
CN-122056283-A Pesticide composition for improving sensitivity of agricultural pests to pesticide and application thereof 华中农业大学 2026-05-19 CN claimed
CN-122056270-A Pesticide suspension concentrate and fertilizer composition thereof 诺力昂化学品国际有限公司 2026-05-19 CN claimed
CN-122005392-A Prinsepia utilis royle allergy-relieving composition and application thereof in sensitive skin care 沭阳源于自然生物科技有限公司 2026-05-12 CN claimed
EP-4734762-A1 BAIT COMPOSITIONS FMC Corporation (US) 2026-05-06 EP claimed
US-12604886-B2 Pest barrier Flint, John (AU) 2026-04-21 US claimed
EP-4723893-A2 COMPOSITIONS AND METHODS TO MITIGATE PHYTOTOXIC EFFECTS OF AGRICHEMICALS Ascribe Bioscience Inc. (US) 2026-04-15 EP claimed
EP-4719059-A1 INCREASED PALATABILITY OF INSECTICIDAL INSECT BAITS Bio Logic Crop Science, S.L. (ES) 2026-04-08 EP claimed
US-20260092926-A1 BIOLOGICAL STATUS CLASSIFICATION RANDOX LABORATORIES LTD (GB) 2026-04-02 US claimed
US-20260083130-A1 NOVEL SULFONATE BENZAMIDE COMPOUNDS FOR CONTROLLING INVERTEBRATE PESTS FMC CORP (US) 2026-03-26 US claimed
US-4388297-A INSECTICIDES THE DOW CHEMICAL COMPANY (US) 1983-06-14 US claimed
EP-0080516-A1 Stable insecticide containing latexes, method of making and method of distributing insecticide THE DOW CHEMICAL COMPANY (US) 1983-06-08 EP claimed
EP-0018707-B1 INSECTICIDAL SYNERGISTIC COMPOSITION CONTAINING O,O-DIETHYL O-(3,5,6-TRICHLORO-2-PYRIDINYL)PHOSPHOROTHIOATE AND O-ETHYL O-(4-(METHYLTHIO)PHENYL)-S-N-PROPYL PHOSPHOROTHIOATE AND METHOD OF CONTROLLING INSECTS THEREWITH THE DOW CHEMICAL COMPANY (US) 1983-05-11 EP claimed
EP-0068297-A1 A new insecticidal composition, processes for its production and its use A. Nattermann & Cie. GmbH (DE) 1983-01-05 EP claimed
US-4341760-A MITICIDES BURROUGHS WELLCOME CO. (US) 1982-07-27 US claimed
US-4320113-A Process for controlling cockroaches and other crawling insects HERCULITE PROTECTIVE FABRICS CORPORATION (US) 1982-03-16 US claimed
US-4303642-A Corn rootworm control THE DOW CHEMICAL COMPANY (US) 1981-12-01 US claimed
US-4250838-A Method for systemic control of parasitic insects FARNAM LIVESTOCK EQUIPMENT AND INSECTICIDES, INC. (US) 1981-02-17 US claimed
US-4228614-A Floating pesticide dispenser ENVIRONMENTAL CHEMICALS, INC. (US) 1980-10-21 US claimed
EP-0006348-A1 Surfactant compositions and biologically active formulations prepared therewith ICI AMERICAS INC. (US) 1980-01-09 EP claimed