Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 8/20 | 0.71 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.64 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.63 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.60 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.57 |
| ▸ | ACHE | P22303 | 3/20 | 0.55 |
| ▸ | BCHE | P06276 | 1/20 | 0.55 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2168147 | 0.95 | LTA4H (0.78) | LTA4HTMEM97SIGMAR1KCNH2SLC6A2 | |
| SCHEMBL2167724 | 0.86 | LTA4H (0.74) | LTA4HKCNH2HRH3TLR9 | |
| SCHEMBL2170260 | 0.83 | LTA4H (1.00) | LTA4HTMEM97SIGMAR1KCNH2HRH3 | |
| SCHEMBL14100524 | 0.81 | LTA4H (0.78) | LTA4HKCNH2TLR9 | |
| SCHEMBL2168554 | 0.81 | LTA4H (0.77) | LTA4HKCNH2HRH3TLR9 | |
| SCHEMBL2168637 | 0.81 | LTA4H (0.69) | LTA4HKCNH2TLR9 | |
| SCHEMBL2168682 | 0.81 | LTA4H (1.00) | LTA4HKCNH2TLR9 | |
| SCHEMBL2167826 | 0.81 | LTA4H (0.80) | LTA4HSIGMAR1KCNH2HRH3TLR9 | |
| SCHEMBL5888823 | 0.79 | SIGMAR1 (1.00) | TMEM97SIGMAR1KCNH2SLC6A2SLC6A4 | |
| SCHEMBL2169516 | 0.79 | LTA4H (1.00) | LTA4HKCNH2TLR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4726238-B2 | — | — | 2011-07-20 | — | — | JP | claimed |
| WO-2005012297-A9 | BENZIMIDAZOLE, BENZTHIAZOLE AND BENZOXAZOLE DERIVATIVES AND THEIR USE AS LTA4H MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2007-01-04 | — | — | WO | claimed |
| EP-1660492-A1 | BENZIMIDAZOLE, BENZTHIAZOLE AND BENZOXAZOLE DERIVATIVES AND THEIR USE AS LTA4H MODULATORS | Janssen Pharmaceutica N.V. (BE) | 2006-05-31 | — | — | EP | claimed |
| WO-2005012297-A1 | BENZIMIDAZOLE, BENZTHIAZOLE AND BENZOXAZOLE DERIVATIVES AND THEIR USE AS LTA4H MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-10 | — | — | WO | claimed |
| US-20050043379-A1 | LTA4H Modulators | JANSSEN PHARMACEUTICA, N.V. (BE) | 2005-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043379-A1 | LTA4H Modulators | LTA4H, LTB4R, LTB4R2 | LTA4H 1/4885TMEM97 3252/4885SIGMAR1 3103/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.