Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 3/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 5/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.36 |
| ▸ | PARP4 | Q9UKK3 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.35 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.35 |
| ▸ | PARP15 | Q460N3 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2168324 | 0.80 | CYP19A1 (0.61) | CYP19A1KDM4ELMNACYP2C19 | |
| SCHEMBL20977973 | 0.78 | PARP10 (0.40) | PARP10MMP2MMP9MMP8CYP2C9 | |
| SCHEMBL9467170 | 0.76 | TSHR (0.47) | CYP19A1MMP2MMP9KDM4ELMNA | |
| SCHEMBL9129817 | 0.73 | CYP19A1 (0.50) | CYP19A1KDM4ELMNACYP2C19 | |
| SCHEMBL2907489 | 0.71 | CYP19A1 (0.70) | CYP19A1 | |
| SCHEMBL10938573 | 0.69 | CYP19A1 (0.44) | CYP19A1KDM4ELMNACYP2C19CREBBP | |
| SCHEMBL5643048 | 0.68 | HSD11B1 (0.40) | PARP10MMP2MMP9MMP8CYP2C19 | |
| SCHEMBL14744167 | 0.66 | PARP1 (0.44) | PARP10PARP2PARP4CA1CA2 | |
| SCHEMBL5645596 | 0.66 | HSD11B1 (0.45) | PARP10LMNACYP2C19PARP2PARP4 | |
| SCHEMBL5642578 | 0.66 | HTR1A (0.38) | PARP10PARP2PARP4CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4732354-B2 | — | — | 2011-07-27 | — | — | JP | claimed |
| EP-1680124-A4 | BICYCLIC [3.1.0] DERIVATIVES AS GLYCINE TRANSPORTER INHIBITORS | PFIZER PROD INC (US) | 2009-05-13 | — | — | EP | claimed |
| JP-2007508374-A | — | — | 2007-04-05 | — | — | JP | claimed |
| EP-1680124-A2 | BICYCLIC [3.1.0] DERIVATIVES AS GLYCINE TRANSPORTER INHIBITORS | Pfizer Products Incorporated (US) | 2006-07-19 | — | — | EP | claimed |
| WO-2005037216-A2 | BICYCLIC [3.1.0] DERIVATIVES AS GLYCINE TRANSPORTER INHIBITORS | PFIZER PRODUCTS INC. (US) | 2005-04-28 | — | — | WO | claimed |