Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21684292 | 0.92 | PRMT5 (0.32) | PRMT5WDR77 | |
| SCHEMBL21685924 | 0.89 | PRMT5 (0.32) | PRMT5WDR77 | |
| SCHEMBL21683387 | 0.89 | PRMT5 (0.32) | PRMT5WDR77 | |
| SCHEMBL31123736 | 0.81 | CYP3A4 (0.30) | PRMT5WDR77 | |
| SCHEMBL21683373 | 0.81 | PRMT5 (0.35) | PRMT5WDR77 | |
| SCHEMBL21684194 | 0.78 | PRMT5 (0.35) | PRMT5WDR77 | |
| SCHEMBL31123795 | 0.77 | PRMT5 (0.32) | PRMT5WDR77 | |
| SCHEMBL31123743 | 0.77 | PRMT5 (0.32) | PRMT5WDR77 | |
| SCHEMBL21683396 | 0.76 | ADK (0.36) | — | |
| SCHEMBL21061581 | 0.76 | PRMT5 (0.34) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3833668-B1 | PRMT5 INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2025-03-19 | — | — | EP | disclosed |
| US-11993602-B2 | PRMT5 inhibitors | MERCK SHARP & DOHME LLC (US) | 2024-05-28 | — | — | US | disclosed |
| US-20210277009-A1 | PRMT5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2021-09-09 | — | — | US | disclosed |
| EP-3833668-A1 | PRMT5 INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2021-06-16 | — | — | EP | disclosed |
| WO-2020033282-A1 | PRMT5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2020-02-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11993602-B2 | PRMT5 inhibitors | PRMT5, PRMT1, PRMT6 | PRMT5 1/4885WDR77 81/4885 |
| US-20210277009-A1 | PRMT5 INHIBITORS | PRMT5, PRMT1, PRMT6 | PRMT5 1/4885WDR77 81/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.