Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Tetrylammonium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.80 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.80 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.80 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.73 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.73 |
| ▸ | ATM | Q13315 | 1/20 | 0.73 |
| ▸ | DNM1 | Q05193 | 4/20 | 0.37 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrylammonium SCHEMBL21268035 | 0.95 | TSHR (0.89) | TSHRNFKB1KCNA1KDM4EPMP22 | |
| Tetrylammonium SCHEMBL25372 | 0.95 | TSHR (0.89) | TSHRNFKB1KCNA1KDM4EPMP22 | |
| Tetrylammonium SCHEMBL5142179 | 0.95 | TSHR (0.89) | TSHRNFKB1KCNA1KDM4EPMP22 | |
| Tetrylammonium SCHEMBL11589433 | 0.90 | KDM4E (0.90) | TSHRNFKB1KCNA1KDM4EPMP22 | |
| Tetrylammonium SCHEMBL1535434 | 0.90 | TSHR (0.80) | TSHRNFKB1KCNA1KDM4EPMP22 | |
| Tetrylammonium SCHEMBL23853867 | 0.90 | TSHR (0.80) | TSHRNFKB1KCNA1KDM4EPMP22 | |
| Tetrylammonium SCHEMBL9130306 | 0.90 | TSHR (0.80) | TSHRNFKB1KCNA1KDM4EPMP22 | |
| Tetrylammonium SCHEMBL9229254 | 0.90 | TSHR (0.80) | TSHRNFKB1KCNA1KDM4EPMP22 | |
| Tetrylammonium SCHEMBL9229252 | 0.90 | TSHR (0.80) | TSHRNFKB1KCNA1KDM4EPMP22 | |
| Tetrylammonium SCHEMBL3176651 | 0.90 | TSHR (0.80) | TSHRNFKB1KCNA1KDM4EPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2355138-B1 | LIQUID COMPOSITION, METHOD OF PRODUCING SILICON SUBSTRATE, AND METHOD OF PRODUCING LIQUID DISCHARGE HEAD SUBSTRATE | CANON KK (JP) | 2016-08-24 | — | — | EP | disclosed |
| CN-102191063-B | Liquid composition, method of producing silicon substrate, and method of producing liquid discharge head substrate | CANON KK | 2014-04-02 | — | — | CN | disclosed |
| US-8492281-B2 | Liquid composition, method of producing silicon substrate, and method of producing liquid discharge head substrate | CANON KABUSHIKI KAISHA (JP) | 2013-07-23 | — | — | US | disclosed |
| US-20120289055-A1 | LIQUID COMPOSITION, METHOD OF PRODUCING SILICON SUBSTRATE, AND METHOD OF PRODUCING LIQUID DISCHARGE HEAD SUBSTRATE | CANON KABUSHIKI KAISHA (JP) | 2012-11-15 | — | — | US | disclosed |
| CN-102191063-A | Liquid composition, method of producing silicon substrate, and method of producing liquid discharge head substrate | CANON KK | 2011-09-21 | — | — | CN | disclosed |
| EP-2355138-A1 | Liquid composition, method of producing silicon substrate, and method of producing liquid discharge head substrate | Canon Kabushiki Kaisha (JP) | 2011-08-10 | — | — | EP | disclosed |
| US-20110183448-A1 | LIQUID COMPOSITION, METHOD OF PRODUCING SILICON SUBSTRATE, AND METHOD OF PRODUCING LIQUID DISCHARGE HEAD SUBSTRATE | CANON KABUSHIKI KAISHA (JP) | 2011-07-28 | — | — | US | disclosed |