Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.46 |
| ▸ | ABAT | P80404 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8159792 | 0.81 | ALDH1A1 (0.55) | ALDH1A1HPGDMAPK1GPR35TP53 | |
| SCHEMBL7108888 | 0.81 | SMN1; SMN2 (0.58) | ALDH1A1HPGDMAPK1GPR35TP53 | |
| SCHEMBL21695800 | 0.77 | ALDH1A1 (0.50) | ALDH1A1HPGDMAPK1GPR35TP53 | |
| SCHEMBL21695798 | 0.75 | GPR35 (0.42) | ALDH1A1HPGDMAPK1GPR35ALOX15 | |
| SCHEMBL15847135 | 0.74 | MAPK1 (0.50) | ALDH1A1HPGDMAPK1GPR35TP53 | |
| SCHEMBL11197700 | 0.74 | MAPK1 (0.50) | ALDH1A1HPGDMAPK1GPR35TP53 | |
| SCHEMBL305116 | 0.73 | MAPT (0.61) | ALDH1A1HPGDMAPK1GPR35TP53 | |
| SCHEMBL9318675 | 0.72 | ALDH1A1 (0.44) | ALDH1A1HPGDMAPK1GPR35TP53 | |
| SCHEMBL306096 | 0.70 | TSHR (0.67) | ALDH1A1HPGDMAPK1GPR35TP53 | |
| SCHEMBL2801920 | 0.70 | GPR35 (0.62) | ALDH1A1HPGDMAPK1GPR35TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4218766-A1 | 1H-PYRROLO[2,3-C]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-C]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS | Incyte Holdings Corporation (US) | 2023-08-02 | — | — | EP | disclosed |
| EP-3674302-A1 | 1H-PYRROLO[2,3-C]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-C]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS | Incyte Corporation (US) | 2020-07-01 | — | — | EP | disclosed |
| EP-3134403-B1 | 1H-PYRROLO[2,3-C]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-C]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS | INCYTE CORP (US) | 2020-02-12 | — | — | EP | disclosed |