Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.51 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15651118 | 0.88 | HSD11B1 (0.62) | HPGDGAALRRK2LMNAALDH1A1 | |
| SCHEMBL15651671 | 0.84 | HPGD (0.63) | HPGDGAALRRK2LMNAALDH1A1 | |
| SCHEMBL6280447 | 0.84 | MCL1 (0.58) | HPGDGAALMNAMCL1ALDH1A1 | |
| SCHEMBL8190808 | 0.84 | ALDH1A1 (0.58) | LMNAALDH1A1MEN1KMT2ACA12 | |
| SCHEMBL15595714 | 0.84 | ALDH1A1 (0.58) | LMNAALDH1A1MEN1KMT2ACA12 | |
| SCHEMBL8190806 | 0.84 | ALDH1A1 (0.58) | LMNAALDH1A1MEN1KMT2ACA12 | |
| SCHEMBL6373713 | 0.83 | LMNA (0.52) | HPGDLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL13753517 | 0.81 | HPGD (0.71) | HPGDGAALMNAALDH1A1MEN1 | |
| SCHEMBL9432665 | 0.80 | ALDH1A1 (0.50) | HPGDGAALMNAMCL1ALDH1A1 | |
| SCHEMBL9873608 | 0.80 | MEN1 (0.49) | HPGDLMNAALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3608317-A1 | COMPOUNDS & METHODS FOR THE ENHANCED DEGRADATION OF TARGETED PROTEINS & OTHER POLYPEPTIDES BY AN E3 UBIQUITIN LIGASE | Yale University (US) | 2020-02-12 | — | — | EP | disclosed |