Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.45 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21696549 | 0.84 | PKM (0.62) | ALDH1A1CYP3A4CYP2C9CYP2C19PKM | |
| SCHEMBL21696497 | 0.84 | ALDH1A1 (0.62) | ALDH1A1CYP3A4CYP2C9CYP2C19PKM | |
| SCHEMBL21696542 | 0.84 | POLB (0.54) | ALDH1A1CYP3A4CYP2C9CYP2C19PKM | |
| SCHEMBL21696977 | 0.84 | POLB (0.54) | ALDH1A1CYP3A4CYP2C9CYP2C19PKM | |
| SCHEMBL21696849 | 0.84 | ALDH1A1 (0.47) | ALDH1A1CYP3A4CYP2C9CYP2C19PKM | |
| SCHEMBL22955244 | 0.84 | ALDH1A1 (0.47) | ALDH1A1CYP3A4CYP2C9CYP2C19PKM | |
| SCHEMBL21696702 | 0.84 | FKBP1A (0.55) | ALDH1A1CYP3A4CYP2C9CYP2C19PKM | |
| SCHEMBL6380737 | 0.84 | FKBP1A (0.59) | ALDH1A1CYP3A4CYP2C9CYP2C19PKM | |
| SCHEMBL21401325 | 0.84 | FKBP1A (0.59) | ALDH1A1CYP3A4CYP2C9CYP2C19PKM | |
| SCHEMBL21696600 | 0.83 | CYP3A4 (0.49) | ALDH1A1CYP3A4CYP2C9CYP2C19PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3608317-A1 | COMPOUNDS & METHODS FOR THE ENHANCED DEGRADATION OF TARGETED PROTEINS & OTHER POLYPEPTIDES BY AN E3 UBIQUITIN LIGASE | Yale University (US) | 2020-02-12 | — | — | EP | disclosed |