Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC5A2 | P31639 | 3/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | AGXT | P21549 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.37 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.35 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | F9 | P00740 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20741882 | 0.86 | CYP2A6 (0.40) | SLC5A2AGXTCYP2A6ADRB2ASIC3 | |
| SCHEMBL21697598 | 0.86 | SLC5A2 (0.42) | SLC5A2SLC5A1AGXTCYP2A6ADRB2 | |
| SCHEMBL20741835 | 0.85 | SLC5A2 (0.44) | SLC5A2SLC5A1AGXTCYP2A6ADRB2 | |
| SCHEMBL16020946 | 0.83 | SLC5A2 (0.39) | SLC5A2CHRM1SLC5A1ADRA1ASLC6A3 | |
| SCHEMBL21697640 | 0.83 | AGXT (0.40) | SLC5A2SLC5A1SLC6A3AGXTCYP2A6 | |
| SCHEMBL21697625 | 0.82 | AGXT (0.36) | SLC5A2AGXTCYP2A6ADRB2ASIC3 | |
| SCHEMBL21697565 | 0.80 | FFAR1 (0.36) | SMN1; SMN2RAB9APTGER1HTR2AHTR2C | |
| SCHEMBL21697576 | 0.78 | CYP2A6 (0.37) | SLC5A2CHRM1SLC5A1ADRA1ASLC6A3 | |
| SCHEMBL21697653 | 0.77 | CYP2A6 (0.40) | SLC5A2AGXTCYP2A6ADRB2ASIC3 | |
| SCHEMBL16018613 | 0.77 | CYP2A6 (0.47) | SLC5A2CHRM1SLC5A1ADRA1ASLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968258-B1 | DUAL SGLT1/SGLT2 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-02-12 | — | — | EP | disclosed |