Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.44 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ACE | P12821 | 3/20 | 0.43 |
| ▸ | PREP | P48147 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 2/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28611516 | 0.82 | CHEK1 (0.45) | NOTUMPOLBACECHEK1JAK2 | |
| SCHEMBL29655525 | 0.82 | CHEK1 (0.45) | NOTUMPOLBACECHEK1JAK2 | |
| SCHEMBL8278531 | 0.81 | NOTUM (0.48) | NOTUMTDP1POLBAPOBEC3AAPOBEC3G | |
| SCHEMBL10116499 | 0.81 | NOTUM (0.48) | NOTUMTDP1POLBAPOBEC3AAPOBEC3G | |
| SCHEMBL16316395 | 0.79 | TDP1 (0.56) | NOTUMTDP1POLBAPOBEC3AAPOBEC3G | |
| SCHEMBL2616888 | 0.79 | NOTUM (0.47) | NOTUMTDP1POLBAPOBEC3AAPOBEC3G | |
| SCHEMBL14569615 | 0.77 | ACE (0.47) | NOTUMTDP1POLBAPOBEC3AAPOBEC3G | |
| SCHEMBL10445427 | 0.77 | GLA (0.45) | NOTUMTDP1POLBAPOBEC3AAPOBEC3G | |
| SCHEMBL32676643 | 0.72 | HTR1A (0.43) | NOTUMTDP1POLBAPOBEC3AAPOBEC3G | |
| SCHEMBL32676817 | 0.72 | HTR1A (0.43) | NOTUMTDP1POLBAPOBEC3AAPOBEC3G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2480247-B1 | NOVEL NPR-B AGONISTS | SHIRE ORPHAN THERAPIES GMBH (DE) | 2020-02-12 | — | — | EP | disclosed |