Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 14/20 | 0.43 |
| ▸ | HTR7 | P34969 | 14/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | ACE | P12821 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR6 | P50406 | 2/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL32676817 | 1.00 | HTR1A (0.43) | HTR1AHTR7NOTUMACEHTR2A | |
| SCHEMBL32676967 | 1.00 | HTR1A (0.43) | HTR1AHTR7NOTUMACEHTR2A | |
| SCHEMBL13619651 | 1.00 | HTR1A (0.43) | HTR1AHTR7NOTUMACEHTR2A | |
| SCHEMBL32676972 | 0.84 | ACE (0.54) | NOTUMACECHEK1JAK2POLB | |
| SCHEMBL3154327 | 0.84 | ACE (0.54) | NOTUMACECHEK1JAK2POLB | |
| SCHEMBL2092090 | 0.84 | ACE (0.54) | NOTUMACECHEK1JAK2POLB | |
| SCHEMBL8278531 | 0.84 | NOTUM (0.48) | NOTUMACECHEK1JAK2POLB | |
| SCHEMBL10116499 | 0.84 | NOTUM (0.48) | NOTUMACECHEK1JAK2POLB | |
| SCHEMBL13971489 | 0.84 | ACE (0.54) | NOTUMACECHEK1JAK2POLB | |
| SCHEMBL32676725 | 0.82 | DPP8 (0.41) | NOTUMHTR2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260049060-A1 | TETRAHYDROISOQUINOLINYLMETHYLBENZAMIDE COMPOUNDS | NATIONAL HEALTH RES INST (TW) | 2026-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260049060-A1 | TETRAHYDROISOQUINOLINYLMETHYLBENZAMIDE COMPOUNDS | OPRK1, OPRD1, OPRM1 | HTR1A 245/4885HTR7 361/4885NOTUM 3574/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.