Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 8/20 | 0.54 |
| ▸ | PPARA | Q07869 | 8/20 | 0.54 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.45 |
| ▸ | CNR2 | P34972 | 2/20 | 0.44 |
| ▸ | MMP12 | P39900 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2356411 | 0.86 | EPHX1 (0.65) | PPARGPPARALTA4HEPHX2EPHX1 | |
| SCHEMBL2171199 | 0.84 | EPHX1 (0.49) | PPARGPPARAEPHX1MMP12MMP13 | |
| SCHEMBL27592490 | 0.81 | EPHX1 (0.68) | EPHX1CNR2CNR1 | |
| SCHEMBL28283094 | 0.80 | CNR2 (0.53) | EPHX1CNR2MMP13HTT | |
| SCHEMBL3391344 | 0.80 | PPARG (0.57) | PPARGPPARACNR2UTS2RHTT | |
| SCHEMBL2172079 | 0.80 | LTA4H (0.45) | PPARGPPARALTA4HEPHX2EPHX1 | |
| SCHEMBL7562926 | 0.78 | FFAR1 (0.50) | PPARGPPARAMMP12MMP13 | |
| SCHEMBL28108266 | 0.77 | EPHX1 (0.77) | PPARGPPARAEPHX1CNR2L3MBTL1 | |
| SCHEMBL11220676 | 0.77 | EPHX1 (0.46) | PPARGPPARAEPHX1 | |
| SCHEMBL7360385 | 0.76 | PPARG (0.48) | PPARGPPARALTA4HEPHX2TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346821-A1 | SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS | Exelixis, Inc. (US) | 2011-07-27 | — | — | EP | disclosed |