Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.44 |
| ▸ | PPARA | Q07869 | 3/20 | 0.43 |
| ▸ | PPARD | Q03181 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 2/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | DRD5 | P21918 | 1/20 | 0.42 |
| ▸ | HRH2 | P25021 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2171199 | 0.92 | EPHX1 (0.49) | EPHX1PPARAPPARGOPRM1OPRD1 | |
| SCHEMBL2170213 | 0.80 | PPARG (0.54) | LTA4HEPHX2EPHX1PPARAPPARG | |
| SCHEMBL2171342 | 0.79 | MMP13 (0.45) | PPARAPPARDLMNA | |
| SCHEMBL27370666 | 0.79 | ALOX5 (0.55) | LTA4HEPHX2FFAR1 | |
| SCHEMBL27370664 | 0.79 | ALOX5 (0.55) | LTA4HEPHX2FFAR1 | |
| SCHEMBL1862136 | 0.77 | LTA4H (0.50) | LTA4HEPHX2PPARAPPARGLMNA | |
| SCHEMBL28151669 | 0.75 | EPHX1 (0.77) | EPHX1PPARAPPARGCNR2 | |
| SCHEMBL1371811 | 0.75 | LTA4H (0.57) | LTA4H | |
| SCHEMBL1371813 | 0.75 | LTA4H (0.57) | LTA4H | |
| SCHEMBL1543801 | 0.74 | AKR1C3 (0.50) | HTR2CDRD3LMNAFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346821-A1 | SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS | Exelixis, Inc. (US) | 2011-07-27 | — | — | EP | disclosed |