Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 9/20 | 0.48 |
| ▸ | PPARA | Q07869 | 9/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | PTGIR | P43119 | 1/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7356441 | 0.89 | EPHX2 (0.42) | PPARGPPARALTA4HEPHX2NR3C1 | |
| SCHEMBL7358523 | 0.83 | MMP12 (0.44) | MMP12MMP13 | |
| SCHEMBL7355708 | 0.81 | PPARG (0.48) | PPARGPPARANR3C1NPY5R | |
| SCHEMBL7356404 | 0.79 | MMP2 (0.44) | LTA4HPGRNPC1ALDH1A1MAPT | |
| SCHEMBL7347546 | 0.78 | RAB9A (0.46) | PPARGPPARANR3C1PGRNPC1 | |
| SCHEMBL7357170 | 0.77 | PPARG (0.46) | PPARGPPARAEPHX2NR3C1SMN1; SMN2 | |
| SCHEMBL2170213 | 0.76 | PPARG (0.54) | PPARGPPARALTA4HEPHX2MMP12 | |
| SCHEMBL7350065 | 0.75 | ALOX5 (0.42) | ALDH1A1SMN1; SMN2NPY5R | |
| SCHEMBL7358996 | 0.72 | HDAC1 (0.42) | PGRMMP12MMP13NPC1ALDH1A1 | |
| SCHEMBL7357356 | 0.71 | ALOX5 (0.54) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1009736-A1 | MALONIC ACID BASED MATRIX METALLOPROTEINASE INHIBITORS | Roche Diagnostics GmbH (DE) | 2000-06-21 | — | — | EP | disclosed |
| WO-1999011608-A1 | MALONIC ACID BASED MATRIX METALLOPROTEINASE INHIBITORS | ROCHE DIAGNOSTICS GMBH (DE) | 1999-03-11 | — | — | WO | disclosed |