Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.37 |
| ▸ | F13A1 | P00488 | 1/20 | 0.35 |
| ▸ | TGM2 | P21980 | 1/20 | 0.35 |
| ▸ | TGM1 | P22735 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | MAOA | P21397 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22423720 | 0.86 | PRSS1 (0.45) | PRSS1TPSAB1HDAC1PHLPP2F13A1 | |
| SCHEMBL25567572 | 0.83 | PHLPP2 (0.49) | PRSS1TPSAB1HDAC1PHLPP2F13A1 | |
| SCHEMBL25570107 | 0.81 | PRSS1 (0.43) | PRSS1TPSAB1HDAC1PHLPP2F13A1 | |
| SCHEMBL25567568 | 0.81 | PRSS1 (0.43) | PRSS1TPSAB1HDAC1PHLPP2F13A1 | |
| SCHEMBL25686449 | 0.81 | PRSS1 (0.45) | PRSS1TPSAB1HDAC1PHLPP2F13A1 | |
| SCHEMBL26560436 | 0.80 | PRSS1 (0.47) | PRSS1TPSAB1HDAC1PHLPP2F13A1 | |
| SCHEMBL25124090 | 0.77 | TPSAB1 (0.42) | PRSS1TPSAB1HDAC1PHLPP2F13A1 | |
| SCHEMBL21896174 | 0.77 | PRSS1 (0.49) | PRSS1TPSAB1PHLPP2TSHRMAOA | |
| SCHEMBL20630435 | 0.75 | PRSS1 (0.53) | PRSS1TPSAB1HDAC1PHLPP2MAOA | |
| SCHEMBL26540306 | 0.74 | PRSS1 (0.44) | PRSS1TPSAB1HDAC1PHLPP2F13A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10711003-B2 | Toll-like receptor 7 (TLR7) agonists having a heterobiaryl moiety, conjugates thereof, and methods and uses therefor | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-07-14 | — | — | US | disclosed |
| US-20200048254-A1 | TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS HAVING A HETEROBIARYL MOIETY, CONJUGATES THEREOF, AND METHODS AND USES THEREFOR | BRISTOL-MYERS SQUIBB COMPANY | 2020-02-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10711003-B2 | Toll-like receptor 7 (TLR7) agonists having a heterobiaryl moiety, conjugates thereof, and methods and uses therefor | TLR7, TLR9, TLR1 | PRSS1 3242/4885TPSAB1 621/4885HDAC1 2158/4885 |
| US-20200048254-A1 | TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS HAVING A HETEROBIARYL MOIETY, CONJUGATES THEREOF, AND METHODS AND USES THEREFOR | TLR7, TLR9, TLR1 | PRSS1 3242/4885TPSAB1 621/4885HDAC1 2158/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.