Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP28 | Q96RU2 | 1/20 | 0.31 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.31 |
| ▸ | KRAS | P01116 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20731201 | 0.83 | ALDH1A1 (0.44) | KDM4E | |
| SCHEMBL23923634 | 0.78 | DPP4 (0.33) | KDM4E | |
| SCHEMBL23923631 | 0.78 | DPP4 (0.33) | KDM4E | |
| SCHEMBL21685589 | 0.77 | JAK1 (0.39) | — | |
| SCHEMBL21704066 | 0.74 | GPR119 (0.40) | KDM4E | |
| SCHEMBL20732207 | 0.73 | KDM4E (0.34) | USP28USP25KRASKDM4E | |
| SCHEMBL20139988 | 0.71 | USP25 (0.38) | USP28USP25KRAS | |
| SCHEMBL24729718 | 0.70 | USP25 (0.60) | USP28USP25 | |
| SCHEMBL24729762 | 0.70 | KDM4E (0.51) | USP28USP25KDM4E | |
| SCHEMBL24729740 | 0.69 | KCNH2 (0.34) | USP28USP25 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020033707-A1 | CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2020-02-13 | — | — | WO | disclosed |