Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | USP25 | Q9UHP3 | 3/20 | 0.34 |
| ▸ | USP28 | Q96RU2 | 2/20 | 0.34 |
| ▸ | KRAS | P01116 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.32 |
| ▸ | CUL4A | Q13619 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.31 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20139988 | 0.79 | USP25 (0.38) | ALDH1A1USP25USP28KRASGAA | |
| SCHEMBL20732209 | 0.78 | — | — | |
| SCHEMBL20731137 | 0.78 | KRAS (0.33) | KDM4EALDH1A1HPGDHTTHIF1A | |
| SCHEMBL20732206 | 0.76 | ALDH1A1 (0.52) | KDM4EALDH1A1HPGDHSD11B1GAA | |
| SCHEMBL21704269 | 0.75 | SSTR5 (0.38) | KDM4EALDH1A1HPGDHTTHIF1A | |
| SCHEMBL21704087 | 0.73 | USP28 (0.31) | KDM4EUSP25USP28KRAS | |
| SCHEMBL21704106 | 0.73 | ALDH1A1 (0.38) | KDM4EALDH1A1HPGDUSP25USP28 | |
| SCHEMBL20732116 | 0.71 | CHRNB2 (0.33) | KDM4EHTTUSP25USP28 | |
| SCHEMBL20732021 | 0.68 | ALDH1A1 (0.47) | KDM4EALDH1A1HPGDHTTHSD11B1 | |
| SCHEMBL20732117 | 0.68 | KRAS (0.38) | KRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020033707-A1 | CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2020-02-13 | — | — | WO | disclosed |
| WO-2019032863-A1 | CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2019-02-14 | — | — | WO | disclosed |