SCHEMBL21709104

SCHEMBL21709104

C#CCOc1cc2c(CCN)c[nH]c2cc1C#C

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR1A P08908 8/20 0.45
HTR1D P28221 7/20 0.45
HTR1B P28222 7/20 0.45
HTR2A P28223 10/20 0.42
TRPM8 Q7Z2W7 4/20 0.42
HTR2C P28335 4/20 0.42
CYP1A2 P05177 2/20 0.42
TSHR P16473 2/20 0.42
HTR7 P34969 2/20 0.42
HTR6 P50406 2/20 0.42
HTR4 Q13639 2/20 0.42
MAPT P10636 2/20 0.42
NFKB1 P19838 1/20 0.42
HTR2B P41595 2/20 0.42
MPO P05164 1/20 0.42
HTR3E A5X5Y0 1/20 0.42
HTR3B O95264 1/20 0.42
CYP3A4 P08684 1/20 0.42
CYP2D6 P10635 1/20 0.42
CYP2C9 P11712 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21709103 0.77 HTR2C (0.57) HTR1AHTR1DHTR1BHTR2ATRPM8
SCHEMBL25057108 0.76 HTR1A (0.72) HTR1AHTR1DHTR1BHTR2ATRPM8
SCHEMBL21708858 0.73 HTR2A (0.42) HTR2AHTR2CHTR2BTAAR1
SCHEMBL21709098 0.72 HTR2A (0.45) HTR1AHTR1DHTR1BHTR2ATRPM8
SCHEMBL7850885 0.70 HTR2A (0.63) HTR1AHTR1DHTR1BHTR2ATRPM8
Hydrochloric Acid SCHEMBL7683721 0.69 NPSR1 (0.64) HTR1AHTR1DHTR1BHTR2ATRPM8
SCHEMBL21708877 0.69 HTR2A (0.39) HTR2ACYP1A2TSHRMAPTNFKB1
SCHEMBL17211932 0.68 HTR1A (0.54) HTR1AHTR1DHTR1BHTR2ATRPM8
SCHEMBL2534666 0.67 HTR1A (0.72) HTR1AHTR1DHTR1BHTR2ATRPM8
SCHEMBL17211933 0.67 HTR2A (0.51) HTR1AHTR1DHTR1BHTR2ATRPM8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020032080-A1 COMPOUND, SALT OF COMPOUND, NEUROMODULATION AGENT, METHOD FOR EVALUATING NEUROMODULATION AGENT, METHOD FOR PRODUCING COMPOUND, AND METHOD FOR PRODUCING SALT OF COMPOUND 学校法人慶應義塾 2020-02-13 WO disclosed