SCHEMBL21709182

SCHEMBL21709182

C#CCOc1ccc(CCNC(=O)OC(C)(C)C)cc1OCC#C

nearest known ligand 0.49

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CA1 P00915 2/20 0.43
CA2 P00918 2/20 0.43
NAMPT P43490 1/20 0.43
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42
GAA P10253 2/20 0.42
CA12 O43570 1/20 0.41
CA9 Q16790 1/20 0.41
CYP3A4 P08684 1/20 0.41
LMNA P02545 1/20 0.41
NQO2 P16083 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2843187 0.85 KMT2A (0.57) MEN1KMT2AGAACYP3A4LMNA
SCHEMBL16930373 0.83 CNR2 (0.48) CA1CA2NAMPTMEN1KMT2A
SCHEMBL6859689 0.83 ALDH1A1 (0.56) CA1CA2KMT2ACA12CA9
SCHEMBL6815439 0.81 CA2 (0.55) CA1CA2MEN1KMT2ACA12
SCHEMBL25300742 0.81 MTNR1A (0.56) NAMPTMEN1KMT2ALMNA
SCHEMBL30517507 0.81 MTNR1A (0.56) NAMPTMEN1KMT2ALMNA
SCHEMBL31432851 0.80 CA12 (0.64) CA1CA2MEN1KMT2AGAA
SCHEMBL903446 0.80 CA12 (0.64) CA1CA2MEN1KMT2AGAA
SCHEMBL6537275 0.76 MTNR1A (0.59) CA1CA2MEN1KMT2ACA12
SCHEMBL19742789 0.76 MTNR1A (0.58) MEN1KMT2ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020032080-A1 COMPOUND, SALT OF COMPOUND, NEUROMODULATION AGENT, METHOD FOR EVALUATING NEUROMODULATION AGENT, METHOD FOR PRODUCING COMPOUND, AND METHOD FOR PRODUCING SALT OF COMPOUND 学校法人慶應義塾 2020-02-13 WO disclosed