SCHEMBL21712865

SCHEMBL21712865

COc1c(C(O)=S)ccc(C(F)F)c1C

nearest known ligand 0.31

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
GRM1 Q13255 1/20 0.31
MEN1 O00255 1/20 0.30
KMT2A Q03164 1/20 0.30
MAPT P10636 1/20 0.30
TDP1 Q9NUW8 1/20 0.30
LMNA P02545 1/20 0.30
MAPK1 P28482 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21712867 0.81 TSHR (0.31) LMNAMAPK1SMN1; SMN2
SCHEMBL21712851 0.80 GRM1 (0.35) GRM1
SCHEMBL20550642 0.79 LMNA (0.35) GRM1MAPTTDP1LMNAMAPK1
SCHEMBL21712866 0.73 LMNA (0.36) GRM1MAPTTDP1LMNAMAPK1
SCHEMBL6218614 0.70 MAPT (0.33) MAPTTDP1LMNAMAPK1SMN1; SMN2
SCHEMBL20425140 0.68 LMNA (0.49) MEN1KMT2AMAPTTDP1LMNA
SCHEMBL11772048 0.67 MAPT (0.52) MEN1KMT2AMAPTTDP1
SCHEMBL11772874 0.66 KMT2A (0.62) MEN1KMT2AMAPTLMNAMAPK1
SCHEMBL25607496 0.66 GRM1 (0.50) GRM1MEN1KMT2AMAPTTDP1
SCHEMBL21712858 0.66 GRM1 (0.36) GRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230183193-A1 4-DIFLUOROMETHYL BENZOYL AMIDES WITH HERBICIDAL ACTION BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2023-06-15 US disclosed
CN-110603250-B Herbicidal 4-difluoromethylbenzamides 拜耳作物科学股份公司 2022-09-30 CN disclosed
EP-3619201-B1 HERBICIDALLY ACTIVE 4-DIFLUORMETHYLBENZOYLAMIDE BAYER CROPSCIENCE AG (DE) 2022-08-10 EP disclosed
EP-3619201-A1 4-DIFLUOROMETHYL BENZOYL AMIDES WITH HERBICIDAL ACTION Bayer CropScience Aktiengesellschaft (DE) 2020-03-11 EP disclosed
US-20200055829-A1 4-DIFLUOROMETHYL BENZOYL AMIDES WITH HERBICIDAL ACTION BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2020-02-20 US disclosed
CN-110603250-A Herbicidal 4-difluoromethylbenzamides 拜耳作物科学股份公司 2019-12-20 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200055829-A1 4-DIFLUOROMETHYL BENZOYL AMIDES WITH HERBICIDAL ACTION DDT, CYP4X1, CBR3 GRM1 363/4885MEN1 4756/4885KMT2A 787/4885
US-20230183193-A1 4-DIFLUOROMETHYL BENZOYL AMIDES WITH HERBICIDAL ACTION DDT, CYP4X1, CBR3 GRM1 363/4885MEN1 4756/4885KMT2A 787/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.