SCHEMBL21712867

SCHEMBL21712867

CCOC(=S)c1ccc(C(F)F)c(C)c1OC

nearest known ligand 0.35

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.31
LMNA P02545 1/20 0.30
MAPK1 P28482 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21712858 0.83 GRM1 (0.36) TSHR
SCHEMBL21712865 0.81 GRM1 (0.31) LMNAMAPK1SMN1; SMN2
SCHEMBL21712866 0.74 LMNA (0.36) LMNAMAPK1SMN1; SMN2
SCHEMBL8309821 0.74 MEN1 (0.33) TSHRLMNAMAPK1SMN1; SMN2
SCHEMBL20550642 0.74 LMNA (0.35) LMNAMAPK1SMN1; SMN2
SCHEMBL17238223 0.68 TSHR (0.53) TSHR
SCHEMBL9303460 0.67 SCN5A (0.35) TSHR
SCHEMBL21712851 0.65 GRM1 (0.35)
SCHEMBL3082599 0.64 TSHR (0.47) TSHRMAPK1SMN1; SMN2
SCHEMBL6553295 0.63 TSHR (0.50) TSHRLMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230183193-A1 4-DIFLUOROMETHYL BENZOYL AMIDES WITH HERBICIDAL ACTION BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2023-06-15 US disclosed
CN-110603250-B Herbicidal 4-difluoromethylbenzamides 拜耳作物科学股份公司 2022-09-30 CN disclosed
EP-3619201-B1 HERBICIDALLY ACTIVE 4-DIFLUORMETHYLBENZOYLAMIDE BAYER CROPSCIENCE AG (DE) 2022-08-10 EP disclosed
EP-3619201-A1 4-DIFLUOROMETHYL BENZOYL AMIDES WITH HERBICIDAL ACTION Bayer CropScience Aktiengesellschaft (DE) 2020-03-11 EP disclosed
US-20200055829-A1 4-DIFLUOROMETHYL BENZOYL AMIDES WITH HERBICIDAL ACTION BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2020-02-20 US disclosed
CN-110603250-A Herbicidal 4-difluoromethylbenzamides 拜耳作物科学股份公司 2019-12-20 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200055829-A1 4-DIFLUOROMETHYL BENZOYL AMIDES WITH HERBICIDAL ACTION DDT, CYP4X1, CBR3 TSHR 175/4885LMNA 3760/4885MAPK1 3774/4885
US-20230183193-A1 4-DIFLUOROMETHYL BENZOYL AMIDES WITH HERBICIDAL ACTION DDT, CYP4X1, CBR3 TSHR 175/4885LMNA 3760/4885MAPK1 3774/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.