Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.42 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.42 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL213580 | 0.86 | LMNA (0.47) | LMNAMAPK1HIF1ACHEK2SMN1; SMN2 | |
| SCHEMBL215715 | 0.84 | LMNA (0.43) | LMNAMAPK1HIF1ACHEK2SMN1; SMN2 | |
| SCHEMBL215873 | 0.83 | CHEK2 (0.53) | LMNAMAPK1HIF1ACHEK2SMN1; SMN2 | |
| SCHEMBL2735426 | 0.77 | ALDH1A1 (0.41) | LMNAMAPK1HIF1ASMN1; SMN2RAF1 | |
| SCHEMBL217151 | 0.76 | CHEK2 (0.57) | LMNAMAPK1HIF1ACHEK2DYRK3 | |
| SCHEMBL213579 | 0.75 | LMNA (0.43) | LMNAMAPK1HIF1ACHEK2SMN1; SMN2 | |
| SCHEMBL216400 | 0.75 | LMNA (0.46) | LMNAMAPK1HIF1ASMN1; SMN2NPSR1 | |
| SCHEMBL2735334 | 0.75 | ALDH1A1 (0.43) | LMNAMAPK1HIF1ASMN1; SMN2NPSR1 | |
| SCHEMBL215714 | 0.74 | LMNA (0.42) | LMNAMAPK1HIF1ACHEK2SMN1; SMN2 | |
| SCHEMBL2735333 | 0.73 | ALDH1A1 (0.42) | LMNAMAPK1HIF1ASMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088767-B2 | JAK-2 modulators and methods of use | EXELIXIS, INC. (US) | 2012-01-03 | — | — | US | disclosed |