Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | FLT1 | P17948 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 2/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2735389 | 0.86 | LMNA (0.45) | CHEK2LMNAMAPK1HIF1AFGFR1 | |
| SCHEMBL215871 | 0.84 | LMNA (0.43) | CHEK2LMNAMAPK1HIF1AFGFR1 | |
| SCHEMBL3327359 | 0.84 | LMNA (0.43) | CHEK2LMNAMAPK1HIF1AFGFR1 | |
| SCHEMBL217150 | 0.83 | LMNA (0.50) | CHEK2LMNAMAPK1HIF1ASMN1; SMN2 | |
| SCHEMBL215460 | 0.82 | LMNA (0.46) | CHEK2LMNAMAPK1HIF1AFGFR1 | |
| SCHEMBL214860 | 0.81 | LMNA (0.45) | CHEK2LMNAMAPK1HIF1APARP1 | |
| SCHEMBL14222350 | 0.80 | LMNA (0.43) | CHEK2LMNAMAPK1HIF1ASMN1; SMN2 | |
| SCHEMBL215366 | 0.80 | LMNA (0.43) | CHEK2LMNAMAPK1HIF1ASMN1; SMN2 | |
| SCHEMBL214297 | 0.79 | EPHX2 (0.44) | CHEK2PARP1HRH3SMN1; SMN2LTA4H | |
| SCHEMBL14222351 | 0.79 | ACHE (0.47) | CHEK2LMNAMAPK1HIF1ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088767-B2 | JAK-2 modulators and methods of use | EXELIXIS, INC. (US) | 2012-01-03 | — | — | US | disclosed |