Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | FPR2 | P25090 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2169794 | 0.88 | ALDH1A1 (0.45) | ALDH1A1MEN1KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL2171837 | 0.88 | ALDH1A1 (0.52) | SCN9AALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL2170387 | 0.87 | ALDH1A1 (0.47) | SCN9AALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2170422 | 0.84 | ALDH1A1 (0.39) | SCN9AALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL2172986 | 0.83 | ALDH1A1 (0.40) | ALDH1A1MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL2173692 | 0.83 | HRH3 (0.41) | ALDH1A1MEN1KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL2170251 | 0.80 | ALDH1A1 (0.57) | ALDH1A1MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL2350975 | 0.78 | TRPV1 (0.50) | ALDH1A1GAA | |
| SCHEMBL2171613 | 0.75 | EPHX2 (0.51) | ALDH1A1SMN1; SMN2MAPTKDM4ELMNA | |
| SCHEMBL11495745 | 0.74 | SLC6A4 (0.52) | SCN9AALDH1A1SIGMAR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346821-A1 | SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS | Exelixis, Inc. (US) | 2011-07-27 | — | — | EP | disclosed |