Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | MMP2 | P08253 | 2/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | FPR2 | P25090 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2169794 | 0.94 | ALDH1A1 (0.45) | ALDH1A1MEN1KMT2AHPGDMMP2 | |
| SCHEMBL2171837 | 0.84 | ALDH1A1 (0.52) | ALDH1A1MEN1KMT2AHPGDKDM4E | |
| SCHEMBL2171604 | 0.84 | SCN9A (0.44) | ALDH1A1MEN1KMT2AHPGDMMP2 | |
| SCHEMBL2170387 | 0.83 | ALDH1A1 (0.47) | ALDH1A1MEN1KMT2AKDM4ESCN9A | |
| SCHEMBL2172986 | 0.82 | ALDH1A1 (0.40) | ALDH1A1MEN1KMT2AMMP2MMP13 | |
| SCHEMBL2173692 | 0.80 | HRH3 (0.41) | ALDH1A1MEN1KMT2AHPGDMMP2 | |
| SCHEMBL2170251 | 0.77 | ALDH1A1 (0.57) | ALDH1A1MEN1KMT2AKDM4ETHRB | |
| SCHEMBL2350975 | 0.74 | TRPV1 (0.50) | ALDH1A1GAA | |
| SCHEMBL2171613 | 0.73 | EPHX2 (0.51) | ALDH1A1KDM4ELMNAGAASMN1; SMN2 | |
| SCHEMBL2170428 | 0.72 | ALDH1A1 (0.47) | ALDH1A1MEN1KMT2AHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349252-A2 | SYNERGISTIC COMBINATION OF SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS AND ANTIMICROTUBULE AGENTS | Exelixis, Inc. (US) | 2011-08-03 | — | — | EP | disclosed |
| EP-2346821-A1 | SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS | Exelixis, Inc. (US) | 2011-07-27 | — | — | EP | disclosed |