Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.51 |
| ▸ | LTA4H | P09960 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2352914 | 0.87 | CYP3A4 (0.48) | ALDH1A1KDM4ESMN1; SMN2LMNACYP3A4 | |
| SCHEMBL2356374 | 0.85 | MAPK14 (0.48) | EPHX2LTA4H | |
| SCHEMBL2357195 | 0.84 | SCN9A (0.45) | EPHX2LTA4HSMN1; SMN2LMNARAB9A | |
| SCHEMBL2172986 | 0.79 | ALDH1A1 (0.40) | ALDH1A1KDM4ESMN1; SMN2LMNACYP3A4 | |
| SCHEMBL2172326 | 0.78 | RORC (0.41) | KDM4ESMN1; SMN2LMNACYP3A4 | |
| SCHEMBL10887924 | 0.77 | KMT2A (0.52) | ALDH1A1SMN1; SMN2LMNARAB9AKCNN4 | |
| SCHEMBL2171837 | 0.75 | ALDH1A1 (0.52) | ALDH1A1KDM4ECYP3A4CYP2C19L3MBTL1 | |
| SCHEMBL2171604 | 0.75 | SCN9A (0.44) | ALDH1A1KDM4ESMN1; SMN2LMNAGAA | |
| SCHEMBL2170387 | 0.74 | ALDH1A1 (0.47) | ALDH1A1KDM4ESMN1; SMN2RAB9A | |
| SCHEMBL2170422 | 0.73 | ALDH1A1 (0.39) | ALDH1A1KDM4ESMN1; SMN2LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346821-A1 | SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS | Exelixis, Inc. (US) | 2011-07-27 | — | — | EP | disclosed |